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Both scenarios have lots of potential for great storytelling. When choosing between them, consider what kind of story you'd most like to tell, and which of the two is going in a direction you find more interesting/compelling. Let me throw some light on the primary differences between the two avenues you're suggesting. Conspiracy If the drug is a secret, ...

Hmm. In situation A you get to work with the theme of a government lying to its people "for their own good"-- security vs. freedom is what that is, and you get to use the secrecy of the drug as a plot device-- who will the girl tell; who will believe her? Who else will find out, and who else already knows? In situation B you get to work with the theme of ...

Have you already considered flipping a coin? I'm not kidding. Ok, the answer "your story, your choice" will not help, even though it is the best answer for your question. So I'm telling you the real question behind your question: "How could I overcome the resistance to write?" Oh, you won't like the answer to this one either: Just write. If you want to ...

I think it needs to be kept secret, scenario 1. Otherwise, curious citizens might have already tried resistance, stopped eating and drinking to see the effects of being off the drug. In either scenario, the drugged population would be apathetic about getting rid of the drug. Their emotions would be suppressed, so they wouldn't rebel, and (in scenario 2) ...